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TCP1 alpha/CCTA antibody
TCP1
Reactivity: Human
WB, IHC
Host: Rabbit
Polyclonal
Poly6190
unconjugated
Product Details anti-TCP1 alpha/CCTA Antibody
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Target
See all TCP1 alpha/CCTA (TCP1) Antibodies
TCP1 alpha/CCTA (TCP1)
(T-Complex 1 (TCP1))
Reactivity
All reactivities for TCP1 alpha/CCTA antibodies
Human
Host
All hosts for TCP1 alpha/CCTA antibodies
Rabbit
Clonality
All clonalities for TCP1 alpha/CCTA antibodies
Polyclonal
Conjugate
All conjugates for TCP1 alpha/CCTA antibodies
This TCP1 alpha/CCTA antibody is un-conjugated
Application
All applications for TCP1 alpha/CCTA antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Cross-Reactivity (Details)
Recognizes ΔN-isoforms
Purification
The antibody was purified by antigen-affinity chromatography.
Clone
Poly6190
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Upon receipt, store frozen at -20°C.
Target Details for TCP1 alpha/CCTA
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Target
TCP1 alpha/CCTA (TCP1)
(T-Complex 1 (TCP1))
Alternative Name
p63 (TCP1 Products )
Synonyms
CCT-alpha antibody, CCT1 antibody, CCTa antibody, D6S230E antibody, TCP-1-alpha antibody, AI528772 antibody, CCT antibody, Cct1 antibody, Ccta antibody, TRic antibody, Tcp-1 antibody, Tp63 antibody, c-cpn antibody, p63 antibody, TRiC antibody, CCTalpha antibody, BEST:GH05123 antibody, CG5374 antibody, Dmel\\CG5374 antibody, T-cpl antibody, TCP-1alpha antibody, TCPA_DROME antibody, Tcp1 antibody, Tcp1-alpha antibody, gh05123 antibody, cct-alpha antibody, ccta antibody, tcp1 antibody, tcp1-a antibody, tcp1a antibody, tcp1alpha antibody, CHUNP6875 antibody, fa13h08 antibody, wu:fa13h08 antibody, wu:fc95g06 antibody, t-complex 1 antibody, T-complex protein 1 subunit alpha antibody, t-complex protein 1 antibody, Tcp1-like antibody, t-complex 1 S homeolog antibody, TCP1 antibody, cct-1 antibody, Tcp1 antibody, T-cp1 antibody, tcp1.S antibody, tcp1 antibody
Background
P63 (ΔN) is a member of the p53 family. This protein has multiple isoforms TA p63-α, -β, γ, ΔN p63-α, -β, and -γ. The molecular weights of the p63 isoforms α=66 kD, β=52 kD, and γ=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. δN isoforms are antagonistic to p53, TA isoforms can transactivate p53 targets. The p63 ΔN isoforms repress TA isoforms, mutant p53 abrogates p63 transactivation. This protein interacts with p53, p73, and the various TA- and ΔN isoforms. The Poly6190 antibody recognizes human p63 ΔN isoforms and has been shown to be useful for Western blotting.
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