Cytochrome C antibody (Cytochrome C, Somatic)

Details for Product anti-CYCS Antibody No. ABIN2666329, Supplier: Log in to see
Antigen
  • CYC
  • HCS
  • THC4
  • cyct
  • cyc
  • hcs
  • CYCS
  • cytc
  • CYCSA
  • CG17903
  • Cyt C
  • Cyt c
  • Cyt-c2
  • CytC-2
  • Cytc
  • Cytc-p
  • DC4
  • DMc01
  • Dmel\\CG17903
  • cyt c
  • cyt c-p
  • cyt-c-p
  • cyt-c2
  • cyt.c
  • cytochrome c
  • dc4
  • pDMc01
  • wu:fk52b01
  • zgc:86706
  • cytochrome c, somatic
  • cytochrome c, somatic S homeolog
  • Cytochrome c proximal
  • cytochrome c, somatic b
  • cytochrome c-like
  • cytochrome c
  • CYCS
  • cycs.S
  • cycs
  • Cycs
  • Cyt-c-p
  • cycsb
  • LOC100724240
  • CYC
  • LOC100847700
  • LOC101107954
  • LOC106829744
  • LOC106992390
Alternatives
anti-Pigeon Cytochrome C antibody for Immunocytochemistry
Reactivity
Broad Bean (Vicia faba), General
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Host
Mouse
301
159
7
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Cytochrome C antibody is un-conjugated
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14
13
8
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Application
Immunofluorescence (IF), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Clone 7H8-2C12
Isotype IgG2a kappa
Purification The antibody was purified by affinity chromatography.
Plasmids, Primers & others Plasmids, Primers & others Cytochrome C products on genomics-online (e.g. as negative or positive controls)
Alternative Name Cytochrome C (CYCS Antibody Abstract)
Background Cytochrome c is a 15 kD protein found in the mitochondrial intermembrane space with a heme-binding domain. Cytochrome c is a component of the electron transport chain, the heme group transfers electrons from cytochrome b-c1 complex to cytochrome oxidase complex. Cytochrome c initiates apoptosis by release to cytoplasm and binding Apaf-1 which activates procaspase 9. Cytochrome c interacts with the cytochrome b-c1 complex, cytochrome oxidase complex, heme, Apaf-1, and Caspase 9 proteins. The 7H8.2C12 monoclonal antibody recognizes cytochrome-c from most species and has been shown to be useful for Western blotting.
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store undiluted between 2°C and 8°C.
Supplier Images
Western Blotting (WB) image for anti-Cytochrome C, Somatic (CYCS) antibody (ABIN2666329) anti-Cytochrome C, Somatic (CYCS) antibody
Background publications Ferguson, Marietta, Van Den Berg: "UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 45793-800, 2003 (PubMed).

Zhang, Gerstein: "The human genome has 49 cytochrome c pseudogenes, including a relic of a primordial gene that still functions in mouse." in: Gene, Vol. 312, pp. 61-72, 2003 (PubMed).

Li, Nijhawan, Budihardjo, Srinivasula, Ahmad, Alnemri, Wang: "Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade." in: Cell, Vol. 91, Issue 4, pp. 479-89, 1997 (PubMed).

Liu, Kim, Yang, Jemmerson, Wang: "Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c." in: Cell, Vol. 86, Issue 1, pp. 147-57, 1996 (PubMed).

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