DC-SIGN/CD209 antibody
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- Target See all DC-SIGN/CD209 (CD209) Antibodies
- DC-SIGN/CD209 (CD209) (CD209)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This DC-SIGN/CD209 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Brand
- BD Pharmingen™
- Characteristics
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The DCN46 antibody specifically binds to dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN or CD209), a type-II membrane protein of approximately 44 kDa with a mannose-binding C-type lectin domain. It is highly expressed on dendritic cells in mucosal tissues. Its sequence is identical to the HIV-1 envelope gp120-binding C-type lectin, and reports suggest that DC-SIGN binds to HIV-1 gp120 and effectively transmits infectious HIV-1 to resting T lymphocytes expressing CD4 and chemokine receptors. The C-type lectin domain of DC-SIGN is also capable of binding other pathogenic viruses, bacteria, and parasites. Reports also suggest that DC-SIGN enables the highly efficient migration of dendritic cells from blood into the tissues. It can interact with ICAM-2, which has a similar sequence as ICAM-3, and is abundantly expressed on vascular and lymphoid endothelium. Thus, DC-SIGN mediates dendritic cells rolling and transendothelial migration, and its interaction with ICAM-2 is essential to specific migratory functions of dendritic cells. Immunohistochemistry of dendritic cells stained for CD209 (DC-SIGN). An acetone-fixed frozen section from human tonsil was stained with the Purified Mouse Anti-Human CD209 antibody. Dendritic cells expressing CD209 (DC-SIGN) can be identified by the intense brown labeling of their cell membranes (magnification 40X).
BD Pharmingen™ Purified Mouse Anti-Human CD209 - Purified - Clone DCN46 - Isotype Mouse IgG2b, κ - Reactivity Hu - 1 mL - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human Monocyte Derived DC Cells
- Clone
- DCN46
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product CD209 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 31.25 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store undiluted at 4°C.
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DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells." in: Cell, Vol. 100, Issue 5, pp. 587-97, (2000) (PubMed).
: "Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses." in: Cell, Vol. 100, Issue 5, pp. 575-85, (2000) (PubMed).
: "DC-SIGN: a guide to some mysteries of dendritic cells." in: Cell, Vol. 100, Issue 5, pp. 491-4, (2000) (PubMed).
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DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells." in: Cell, Vol. 100, Issue 5, pp. 587-97, (2000) (PubMed).
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- Target
- DC-SIGN/CD209 (CD209) (CD209)
- Alternative Name
- CD209 (CD209 Products)
- Synonyms
- CDSIGN antibody, CLEC4L antibody, DC-SIGN antibody, DC-SIGN1 antibody, cd209 antibody, CLEC4M antibody, si:ch211-224h1.3 antibody, CD209 antibody, CIRE antibody, Dcsign antibody, SIGN-R1 antibody, SIGNR5 antibody, Cd209 antibody, CD209 molecule antibody, CD209a antigen antibody, CD209 antigen-like protein D antibody, CD209c molecule antibody, CD209 antigen antibody, CD209 antibody, cd209 antibody, Cd209a antibody, LOC100529184 antibody, Cd209c antibody, LOC100460708 antibody, LOC105484282 antibody
- Background
- Synonyms: DC-SIGN
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