CD36 antibody

Catalog No. ABIN2689209

Product Details anti-CD36 Antibody

Target: CD36

Reactivity: Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD36 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Functional Studies (Func)

Brand: BD Pharmingen™

Characteristics: The CRF D-2712 antibody reacts with mouse and rat CD36, an 88- kDa glycoprotein member of the class B scavenger receptor family. CD36 is a multifunctional receptor which has a variety of ligands and is expressed on many cell types. Consequently, it is known by several names, including macrophage scavenger receptor, platelet glycoprotein IV, and fatty acid translocase. Cells which express CD36 include platelets, megakaryocytes, monocytes/macrophages, dendritic cells, erythroid precursors, microvascular endothelia, skeletal, cardiac, and smooth muscle cells, adipocytes, and epithelia of retina, breast, and intestine. Therefore, we would not expect to detect CD36 expression by flow cytometry of leukocytes isolated from naive peripheral lymphoid tissues. This multi-ligand receptor functions in the clearance of apoptotic cells and abnormal erythrocytes (in malaria and sickle-cell anemia), the transport of long-chain fatty acids and oxidized low-density lipoproteins, the regulation of angiogenesis by mediating the effects of thrombospondin-1, and the mediation of coronary vasoconstriction. Cross-linking of cell-surface CD36 with plate-bound CRF D-2712 mAb promotes internalization of photoreceptor outer segment fragments by cultured retinal pigment epithelium.

BD Pharmingen™ Purified Mouse Anti-Mouse CD36 - Purified - Clone CRF D-2712 - Isotype Mouse IgA, κ - Reactivity Ms, Rat - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Recombinant mouse CD36

Clone: CRF D

Isotype: IgA kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD36 antibody (ABIN2689209)

Bodart, Febbraio, Demers, McNicoll, Pohankova, Perreault, Sejlitz, Escher, Silverstein, Lamontagne, Ong: "CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart." in: Circulation research, Vol. 90, Issue 8, pp. 844-9, (2002) (PubMed).

Febbraio, Hajjar, Silverstein: "CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism." in: The Journal of clinical investigation, Vol. 108, Issue 6, pp. 785-91, (2001) (PubMed).

Finnemann, Silverstein: "Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium." in: The Journal of experimental medicine, Vol. 194, Issue 9, pp. 1289-98, (2001) (PubMed).

Target Details for CD36

Target: CD36

Alternative Name: CD36 (CD36 Products)

Synonyms: BDPLT10 antibody, CHDS7 antibody, FAT antibody, GP3B antibody, GP4 antibody, GPIV antibody, PASIV antibody, SCARB3 antibody, Fat antibody, Scarb3 antibody, GPIIIB antibody, PAS-4 antibody, zgc:92513 antibody, CD36 molecule antibody, CD36 molecule (thrombospondin receptor) antibody, CD36 antibody, Cd36 antibody, cd36 antibody

Background: Synonyms: Scavenger Receptor

Pathways: TLR Signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteins