CD58 antibody

Catalog No. ABIN2689345

Product Details anti-CD58 Antibody

Target: CD58

Reactivity: Human, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD58 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with a 60-70 kDa membrane glycoprotein member of the immunoglobulin superfamily. CD58, also referred to as the lymphocyte function-associated antigen-3 (LFA-3), has a wide tissue distribution, being expressed on both hematopoietic and non-hematopoietic cells, including endothelial cells and fibroblasts. There are two isoforms of CD58: a glycosylphosphatidylinositol (GPI)-linked formed and a transmembrane form. Both isoforms may be expressed in the same cell type. Erythrocytes, however, only have the GPI-linked isoform. CD58 interacts with CD2 during cell adhesion. This binding can enhance antigen-specific T-cell activation. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed on a FACScan

BD Pharmingen™ Purified Mouse Anti-Human CD58 - Purified - Clone 1C3 (also known as AICD58) - Isotype Mouse IgG2a, κ - Reactivity Hu, Dog - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: 1C3

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD58 antibody (ABIN2689345)

Dengler, Hoffmann, Knolle, Albert-Wolf, Roux, Wallich, Meuer: "Structural and functional epitopes of the human adhesion receptor CD58 (LFA-3)." in: European journal of immunology, Vol. 22, Issue 11, pp. 2809-17, (1992) (PubMed).

Target Details for CD58

Target: CD58

Alternative Name: CD58 (CD58 Products)

Synonyms: LFA-3 antibody, LFA3 antibody, ag3 antibody, CD58 molecule antibody, CD58 antibody

Background: Synonyms: LFA-3