Survivin antibody (AA 1-142)

Catalog No. ABIN2738580

Product Details anti-Survivin Antibody

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Binding Specificity: AA 1-142

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Survivin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Human BIRC5 / Survivin

Purification: Immunoaffinity purified

Immunogen: Human recombinant protein (aa M1-D142).

Type of Immunogen: Recombinant protein

Isotype: IgG

Application Details

Application Notes: Approved: ELISA (0.1 - 0.5 μg/mL), IHC, IHC-P (0.5 - 1 μg/mL), WB (0.5 - 1 μg/mL)

Usage: Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. It is a member of the inhibitor of apoptosis (IAP) family. The gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and two-color FISH. The Survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. It is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Sterile distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS, 0.025 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Target Details for Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Alternative Name: BIRC5 / Survivin (BIRC5 Products)

Synonyms: AP14 antibody, API4 antibody, EPR-1 antibody, AAC-11 antibody, Api4 antibody, TIAP antibody, survivin40 antibody, bir5a antibody, survivin antibody, BIR1 antibody, Su2 antibody, XBIR1 antibody, XSurvivin1 antibody, Xsvv1 antibody, api4 antibody, bir1-A antibody, epr-1 antibody, svv1 antibody, xSurvivin antibody, xsurv antibody, Su1 antibody, birc5.2 antibody, svv2 antibody, xSurvivin2 antibody, bir5b antibody, SIX antibody, birc5.2-a antibody, birc5.2-b antibody, baculoviral IAP repeat containing 5 antibody, baculoviral IAP repeat-containing 5 antibody, baculoviral IAP repeat containing 5a antibody, baculoviral IAP repeat-containing 5, gene 1 L homeolog antibody, baculoviral IAP repeat containing 5 L homeolog antibody, baculoviral IAP repeat containing 5b antibody, baculoviral IAP repeat containing 5 S homeolog antibody, BIRC5 antibody, Birc5 antibody, birc5a antibody, birc5.1.L antibody, birc5.2.L antibody, birc5b antibody, birc5.2.S antibody

Background: Name/Gene ID: BIRC5
Family: Apoptosis

Synonyms: BIRC5, API4, Apoptosis inhibitor survivin, Apoptosis inhibitor 4, Survivin, Survivin variant 3 alpha, EPR-1, IAP4

Gene ID: 332

Pathways: Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding