14-3-3 sigma/SFN antibody (Internal Region)
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- Target See all 14-3-3 sigma/SFN (SFN) Antibodies
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This 14-3-3 sigma/SFN antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- Human SFN / Stratifin / 14-3-3 Sigma
- Purification
- Protein A purified
- Immunogen
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A recombinant protein fragment from the internal region of 14-3-3 sigma.
Type of Immunogen: Recombinant protein - Isotype
- IgG
- Top Product
- Discover our top product SFN Primary Antibody
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- Application Notes
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Approved: WB (1 - 3 μg/mL)
Usage: 14-3-3 proteins are regulators of a diverse group of signaling proteins, including kinases, phosphatases, and transmembrane receptors, and have roles in a wide range of physiological processes including transcription, intracellular signaling, cell cycle control and apoptosis. There are seven 14-3-3 proteins in most mammals: beta, gamma epsilon, zeta, eta, sigma and tau. 14-3-3 sigma, also called Stratifin, is a product of the SFN gene. It is a tumor suppressor gene inactivated via DNA methylation. Reduced or no expression of 14-3-3 sigma is seen in various carcinoma including skin, breast and prostate, suggesting that 14-3-3 gene silencing may be involved in tumor progression. - Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- avoid freeze thaw cycles
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze-thaw cycles.
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- Target
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
- Alternative Name
- SFN / Stratifin / 14-3-3 sigma (SFN Products)
- Synonyms
- YWHAS antibody, Er antibody, Mme1 antibody, Ywhas antibody, stratifin antibody, SFN antibody, Sfn antibody
- Background
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Name/Gene ID: SFN
Synonyms: SFN, 14-3-3 sigma, 14-3-3 protein sigma, HME1, Stratifin, YWHAS - Gene ID
- 2810
- Pathways
- p53 Signaling, Myometrial Relaxation and Contraction
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