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FAS antibody
FAS
Reactivity: Human
WB, FACS, IP, Func
Host: Mouse
Monoclonal
APO-1-3
unconjugated
Product Details anti-FAS Antibody
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Target
See all FAS Antibodies
FAS
(TNF Receptor Superfamily, Member 6 (FAS))
Reactivity
All reactivities for FAS antibodies
Human
Host
All hosts for FAS antibodies
Mouse
Clonality
All clonalities for FAS antibodies
Monoclonal
Conjugate
All conjugates for FAS antibodies
This FAS antibody is un-conjugated
Application
All applications for FAS antibodies
Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
Specificity
Recognizes human Fas.
Cross-Reactivity
Human
Purity
>95 % (SDS-PAGE)
Immunogen
Recombinant human Fas.
Clone
APO-1-3
Isotype
IgG3
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Discover our top product FAS Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
Lot specific
Buffer
In PBS.
Preservative
Without preservative
Storage
4 °C,-20 °C
Storage Comment
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date
12 months
Target Details for FAS
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Target
FAS
(TNF Receptor Superfamily, Member 6 (FAS))
Alternative Name
Fas (FAS Products )
Synonyms
ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody
Background
Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappaB.
UniProt
P25445
Pathways
p53 Signaling , Apoptosis , Production of Molecular Mediator of Immune Response , Positive Regulation of Endopeptidase Activity
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