This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: ERLEC2, OS-9
Protein Interaction Partner: SYVN1, SEL1L, UBC, DCSTAMP, SERPINI1, FBXO6, EGFR, DERL2, CLN5, SNRPD2, SMAD2, FOXM1, ACVR1B, ZNF512B, env, CREB3, RBX1, UBE2J1, CERCAM, NUP210, OS9, HYOU1, VCP, HSP90B1, PPIB, PLOD2, HSPA5, SERPINH1, BSG, FOXRED2, COLGALT1, UGGT2, DNAJB11, ERLEC1, HIF1A,
Protein Size: 667