UBE2L3 antibody (C-Term)
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- Target See all UBE2L3 Antibodies
- UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This UBE2L3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against UBE2L3. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human UBE2L3
- Top Product
- Discover our top product UBE2L3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 668 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
- Alternative Name
- UBE2L3 (UBE2L3 Products)
- Synonyms
- E2-F1 antibody, L-UBC antibody, UBCH7 antibody, UbcM4 antibody, C79827 antibody, Ubce7 antibody, ube2l3 antibody, wu:fc22h11 antibody, zgc:86727 antibody, UBE2L3 antibody, ube2l3l antibody, wu:fb38h03 antibody, ubiquitin conjugating enzyme E2 L3 antibody, ubiquitin-conjugating enzyme E2L 3 antibody, ubiquitin-conjugating enzyme E2L 3a antibody, ubiquitin conjugating enzyme E2 L3 S homeolog antibody, ubiquitin-conjugating enzyme E2L 3b antibody, UBE2L3 antibody, Ube2l3 antibody, ube2l3a antibody, ube2l3.S antibody, ube2l3b antibody
- Background
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
Alias Symbols: E2-F1, L-UBC, UBCH7, UbcM4
Protein Interaction Partner: UBC, TRAF6, NEDD4, ITCH, MUL1, SMURF2, SMURF1, WWP2, WWP1, ARIH2, RNF144A, UBA1, PARK2, RNF144B, HACE1, ARIH1, UBE3A, UBE2L3, UBA6, UBR5, CACNA1B, MAP1LC3B, BAG3, HSPA4, AICDA, CCNB1IP1, FN1, RBX1, LIG4, ZPR1, USP9X, SF1, VDAC2, UCHL3, UBE2V2, UBE2D2, UBE
Protein Size: 668 - Molecular Weight
- 75 kDa
- Gene ID
- 7332
- NCBI Accession
- NM_004739, NP_003338
- UniProt
- P68036
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