SCN8A antibody (C-Term)

Catalog No. ABIN2776200

The Rabbit Polyclonal anti-SCN8A antibody is suitable to detect SCN8A in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Horse and Pig. It has been validated for WB and IHC.

Quick Overview for SCN8A antibody (C-Term) (ABIN2776200)

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN8A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SCN8A Antibody

Binding Specificity: C-Term

Sequence: KSSIFSFRGP GRFRDPGSEN EFADDEHSTV EESEGRRDSL FIPIRARERR

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SCN8A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human SCN8A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SCN8A

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Alternative Name: SCN8A

Background: This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.
Alias Symbols: MED, PN4, CIAT, NaCh6, CERIII, EIEE13, Nav1.6
Protein Size: 475

Molecular Weight: 52 kDa

Gene ID: 6334

NCBI Accession: NM_001177984, NP_001171455

UniProt: Q9UQD0

Pathways: Sensory Perception of Sound