SCN8A antibody (Internal Region)

Catalog No. ABIN6263505

The Rabbit Polyclonal anti-SCN8A antibody is suitable to detect SCN8A in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IF and ICC.

Quick Overview for SCN8A antibody (Internal Region) (ABIN6263505)

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN8A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-SCN8A Antibody

Binding Specificity: Internal Region

Specificity: Nav1.6/SCN8A Antibody detects endogenous levels of total Nav1.6/SCN8A.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Nav1.6/SCN8A, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SCN8A

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Alternative Name: SCN8A

Background:

Description: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.

Gene: SCN8A

Molecular Weight: 225 kDa

Gene ID: 6334

UniProt: Q9UQD0

Pathways: Sensory Perception of Sound