SCN8A antibody (AA 1854-1951)

Catalog No. ABIN520023

Cited in 1 publication. The Mouse Monoclonal anti-SCN8A antibody (Clone 4G7) (ABIN520023) specifically detects SCN8A in WB, ELISA and IF. The antibody is reactive with Human samples.

Quick Overview for SCN8A antibody (AA 1854-1951) (ABIN520023)

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SCN8A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 4G7

Product Details anti-SCN8A Antibody

Binding Specificity: AA 1854-1951

Purpose: Mouse monoclonal antibody raised against a partial recombinant SCN8A.

Sequence: RVLGDSGELD ILRQQMEERF VASNPSKVSY EPITTTLRRK QEEVSAVVLQ RAYRGHLARR GFICKKTTSN KLENGGTHRE KKESTPSTAS LPSYDSVT

Cross-Reactivity: Human, Mouse

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: SCN8A (NP_055006, 1854 a.a. ~ 1951 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-SCN8A antibody (ABIN520023)

Ogiwara, Miyamoto, Morita, Atapour, Mazaki, Inoue, Takeuchi, Itohara, Yanagawa, Obata, Furuichi, Hensch, Yamakawa: "Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 22, pp. 5903-14, (2007) (PubMed).

Target Details for SCN8A

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Alternative Name: SCN8A

Background: Full Gene Name: sodium channel, voltage gated, type VIII, alpha subunit
Synonyms: CerIII,MED,NaCh6,Nav1.6,PN4

Gene ID: 6334

NCBI Accession: NM_014191

Pathways: Sensory Perception of Sound