SCN8A antibody

Catalog No. ABIN7075647

The Rabbit Polyclonal anti-SCN8A antibody is suitable to detect SCN8A in samples from Mouse and Rat. It has been validated for WB, IHC and IF.

Quick Overview for SCN8A antibody (ABIN7075647)

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN8A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SCN8A Antibody

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Nav1.6/SCN8A

Application Details

Application Notes: WB (M) 1:300-1:600, IHC/IF (M,R) 1:600-1:1200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for SCN8A

Target: SCN8A (Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Alternative Name: Nav1.6/SCN8A

Background: This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.

Molecular Weight: 225 kDa

Gene ID: 20273

UniProt: Q9WTU3

Pathways: Sensory Perception of Sound