Insulin Receptor antibody (Middle Region)

Catalog No. ABIN2776773

This Rabbit Polyclonal antibody specifically detects Insulin Receptor in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit and Sheep.

Quick Overview for Insulin Receptor antibody (Middle Region) (ABIN2776773)

Target: Insulin Receptor (INSR)

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Insulin Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Insulin Receptor Antibody

Binding Specificity: Middle Region

Purpose: Insr Antibody - middle region

Sequence: EEVSGTKGRQ ERNDIALKTN GDQASCENEL LKFSFIRTSF DKILLRWEPY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against Insr. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41373-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Insulin Receptor

Target: Insulin Receptor (INSR)

Alternative Name: Insr

Background:

Background Information: This receptor binds insulin and has a tyrosine-protein kinase activity. When it is present in a hybrid receptor with IGF1R, binds IGF1.

Gene Name: Insulin receptor

Alternative Symbols: I, IR, IR-A, IR-B, CD220, 4932439J01Rik, D630014A15Rik

Protein Name: Insulin receptor

Molecular Weight: 155kDa

Gene ID: 16337

NCBI Accession: NP_034698

UniProt: P15208

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity