c-MYC antibody (N-Term)

Catalog No. ABIN2779313

The Rabbit Polyclonal anti-c-MYC antibody has been validated for WB. It is suitable to detect c-MYC in samples from Human, Mouse, Rat, Dog, Cow, Sheep, Rabbit, Guinea Pig, Zebrafish (Danio rerio) and Horse. There is 1 publication available.

Quick Overview for c-MYC antibody (N-Term) (ABIN2779313)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivity: Human, Mouse, Rat, Dog, Cow, Sheep, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MYC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-c-MYC Antibody

Binding Specificity: N-Term

Sequence: QPYFYCDEEE NFYQQQQQSE LQPPAPSEDI WKKFELLPTP PLSPSRRSGL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against MYC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MYC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 454 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-c-MYC antibody (ABIN2779313)

Mallampalli, Kaercher, Snavely, Pulijala, Chen, Coon, Zhao, Agassandian: "Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I." in: Cellular signalling, Vol. 25, Issue 10, pp. 2047-59, (2013) (PubMed).

Target Details for c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Alternative Name: Myc Proto-Oncogene protein

Background: MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: c-Myc, MRTL, bHLHe39
Protein Interaction Partner: UBC, USP37, USP22, KDM1A, SKP2, SMAD7, SNRNP70, CEP57, LDOC1, BRD3, KIDINS220, MAX, CSNK2B, CSNK2A1, USP28, NMI, PFDN5, TP73, EP400, SP1, PIAS2, ZBTB17, IGF2BP3, PTRF, SDK1, MRPL53, PRKCDBP, PHLDB2, KNDC1, MZT2B, RIN3, NEK11, MICALL2, NLRX1, NABP2, MYC, M
Protein Size: 454

Molecular Weight: 50 kDa

Gene ID: 4609

NCBI Accession: NM_002467, NP_002458

Pathways: p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect