TNFSF15 antibody (C-Term)

Catalog No. ABIN2779354

Product Details anti-TNFSF15 Antibody

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF15 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CSEIRQAGRP NKPDSITVVI TKVTDSYPEP TQLLMGTKSV CEVGSNWFQP

Predicted Reactivity: Cow: 79%, Human: 100%, Mouse: 100%

Characteristics: This is a rabbit polyclonal antibody against TNFSF15. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human TNFSF15

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Alternative Name: TNFSF15 (TNFSF15 Products)

Synonyms: TTPAL antibody, TL1 antibody, TL1A antibody, VEGI antibody, VEGI192A antibody, Tl1 antibody, Tl1a antibody, Vegi antibody, tumor necrosis factor superfamily member 15 antibody, TNF superfamily member 15 antibody, tumor necrosis factor (ligand) superfamily, member 15 antibody, TNFSF15 antibody, Tnfsf15 antibody

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.
Protein Interaction Partner: TNFRSF25, TNFRSF6B,
Protein Size: 192

Molecular Weight: 21 kDa

Gene ID: 9966

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy