PTGES2 antibody (Middle Region)

Catalog No. ABIN2780102

Product Details anti-PTGES2 Antibody

Target: PTGES2 (Prostaglandin E Synthase 2 (PTGES2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGES2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GAAAMYLISK RLKSRHHLQD DVRVDLYEAA NKWVTAVGKD RPFMGGQKPN

Predicted Reactivity: Cow: 92%, Dog: 86%, Guinea Pig: 93%, Horse: 100%, Human: 79%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Ptges2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Ptges2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTGES2

Target: PTGES2 (Prostaglandin E Synthase 2 (PTGES2))

Alternative Name: Ptges2 (PTGES2 Products)

Synonyms: C9orf15 antibody, GBF-1 antibody, GBF1 antibody, PGES2 antibody, mPGES-2 antibody, Pges antibody, 2410099E23Rik antibody, D2Ertd369e antibody, mPGES antibody, mPGES-1 antibody, PTGES2 antibody, ptges2 antibody, zgc:56527 antibody, gbf1 antibody, pges2 antibody, 0610038H10Rik antibody, C79137 antibody, Gbf1 antibody, Mpges2 antibody, Pges2 antibody, MPGES-2 antibody, prostaglandin E synthase 2 antibody, prostaglandin E synthase antibody, prostaglandin E synthase 2-like antibody, PTGES2 antibody, Ptges antibody, Ptges2 antibody, ptgesl antibody, CpipJ_CPIJ003988 antibody, CpipJ_CPIJ018524 antibody, ptges2 antibody

Background: The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta.
Alias Symbols: 0610038H10Rik, C79137, Gbf1, Mpges2, Pges2
Protein Size: 384

Molecular Weight: 43 kDa

Gene ID: 96979

NCBI Accession: NM_133783, NP_598544

UniProt: Q8BWM0

Pathways: Interferon-gamma Pathway, Cell RedoxHomeostasis, SARS-CoV-2 Protein Interactome