RFX1 antibody (Middle Region)
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- Target See all RFX1 Antibodies
- RFX1 (Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Saccharomyces cerevisiae
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RFX1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EDTDLSRLYT ATSLMQIDDN VMRKFHGYNS LKEYYEEESC MRYLHRIYVP
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 90%, Human: 100%, Mouse: 100%, Rat: 100%, Yeast: 100%
- Characteristics
- This is a rabbit polyclonal antibody against RFX1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human RFX1
- Top Product
- Discover our top product RFX1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 979 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- RFX1 (Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1))
- Alternative Name
- RFX1 (RFX1 Products)
- Synonyms
- EFC antibody, RFX antibody, AI047719 antibody, AI385641 antibody, zgc:162914 antibody, regulatory factor X1 antibody, regulatory factor X, 1 (influences HLA class II expression) antibody, regulatory factor X, 1a (influences HLA class II expression) antibody, RFX1 antibody, Rfx1 antibody, rfx1a antibody
- Background
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RFX1 is a member of the regulatory factor X protein family, which are transcription factors that contain a highly-conserved winged helix DNA binding domain. RFX1 is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EF-C, EFC, RFX
Protein Interaction Partner: SOX2, SMAD9, SMAD4, SMAD1, NOTCH1, Cebpb, NCOA3, HDAC1, NFIC, NFIB, TADA3, RFX3, MAGED1, ABL1, NFIX, HMGB1, HIVEP2, RFX2, ADD1,
Protein Size: 979 - Molecular Weight
- 105 kDa
- Gene ID
- 5989
- NCBI Accession
- NM_002918, NP_002909
- UniProt
- P22670
- Pathways
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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