NR1D2 antibody (C-Term)
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- Target See all NR1D2 Antibodies
- NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Mouse, Dog, Rabbit, Cow, Horse, Guinea Pig, Zebrafish (Danio rerio), Sheep
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NR1D2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- ETLIRALRTL IMKNHPNEAS IFTKLLLKLP DLRSLNNMHS EELLAFKVHP
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 92%, Zebrafish: 93%
- Characteristics
- This is a rabbit polyclonal antibody against NR1D2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human NR1D2
- Top Product
- Discover our top product NR1D2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 579 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))
- Alternative Name
- NR1D2 (NR1D2 Products)
- Synonyms
- BD73 antibody, EAR-1R antibody, RVR antibody, HZF-2 antibody, Rev-erb antibody, REV-ERBB antibody, NR1D2 antibody, rvr antibody, bd73 antibody, hzf2 antibody, ear-1r antibody, hs.37288 antibody, NR1D2-A antibody, Reverbbeta-A antibody, reverbb1 antibody, reverbb antibody, reverbb2 antibody, zgc:92019 antibody, nuclear receptor subfamily 1 group D member 2 antibody, nuclear receptor subfamily 1, group D, member 2 antibody, nuclear receptor subfamily 1, group D, member 2a antibody, nuclear receptor subfamily 1, group D, member 2b antibody, NR1D2 antibody, Nr1d2 antibody, nr1d2 antibody, nr1d2a antibody, nr1d2b antibody
- Background
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NR1D2 can interact with NCOA5 coactivator, leading to a strong increase of transcription of target genes. NR1D2 also binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3' and acts as a potent competitive transcriptional silencer and negative regulator of RORalpha mediated trans-activation. NR1D2 may play different roles in metabolism, inflammation, and circadian cycling in the organ-specific manner in homeostasis.
Alias Symbols: RVR, BD73, EAR-1R
Protein Interaction Partner: MID2, RBPMS, TRIM27, NOTCH2NL, KRTAP10-9, KRT40, KRTAP4-2, PRMT6, SKP1, UBC, SIN3B, KAT5, NCOR1, TAF9, TAF6, HDAC1, GTF2B, NCOA5, UBE2I, CUL1, NR1D1, RGN,
Protein Size: 579 - Molecular Weight
- 65 kDa
- Gene ID
- 9975
- NCBI Accession
- NM_005126, NP_005117
- UniProt
- Q14995
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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