PAI1 antibody (C-Term)

Catalog No. ABIN2782977

This Rabbit Polyclonal antibody specifically detects PAI1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Pig, Dog, Cow, Sheep, Horse, Guinea Pig, Goat and Zebrafish (Danio rerio).It has been mentioned in 1 publication

Quick Overview for PAI1 antibody (C-Term) (ABIN2782977)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reactivity: Human, Mouse, Rat, Rabbit, Pig, Dog, Cow, Sheep, Horse, Guinea Pig, Goat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAI1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PAI1 Antibody

Binding Specificity: C-Term

Purpose: SERPINE1 Antibody - C-terminal region

Sequence: VNESGTVASS STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 85%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against SERPINE1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SERPINE1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8108306

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-PAI1 antibody (ABIN2782977)

Penco, Buscema, Patrosso, Marocchi, Grossi: "New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background." in: BMC bioinformatics, Vol. 9, pp. 254, (2008) (PubMed).

Target Details for PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Alternative Name: SERPINE1

Background:

Background Information: SERPINE1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.

Gene Name: Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Alternative Symbols: PAI, PAI1, PAI-1, PLANH1

Protein Name: Plasminogen activator inhibitor 1

Molecular Weight: 43kDa

Gene ID: 5054

NCBI Accession: NP_000593

UniProt: P05121

Pathways: p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration