HLA-DQA2 antibody (Middle Region)

Catalog No. ABIN2783760

Product Details anti-HLA-DQA2 Antibody

Target: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Sheep, Cow, Goat, Rabbit, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DQA2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LPMFSKFISF DPQSALRNMA VGKHTLEFMM RQSNSTAATN EVPEVTVFSK

Predicted Reactivity: Cow: 86%, Goat: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 86%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against HLA-DQA2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HLA-DQA2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 255 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HLA-DQA2

Target: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Alternative Name: HLA-DQA2 (HLA-DQA2 Products)

Synonyms: DX-ALPHA antibody, HLA-DXA antibody, major histocompatibility complex, class II, DQ alpha 2 antibody, HLA-DQA2 antibody

Background: This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells.
Alias Symbols: DQ alpha, HLA-DXA, DX-ALPHA
Protein Interaction Partner: UBC, HLA-DQB1, CD4, INS,
Protein Size: 255

Molecular Weight: 28 kDa

Gene ID: 3118

NCBI Accession: NM_020056, NP_064440

UniProt: P01906

Pathways: TCR Signaling, Human Leukocyte Antigen (HLA) in Adaptive Immune Response