BSCL2 antibody (C-Term)

Catalog No. ABIN2784048

The Rabbit Polyclonal anti-BSCL2 antibody (ABIN2784048) specifically detects BSCL2 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Rabbit and Horse samples.

Quick Overview for BSCL2 antibody (C-Term) (ABIN2784048)

Target: BSCL2 (Berardinelli-Seip Congenital Lipodystrophy 2 (Seipin) (BSCL2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BSCL2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BSCL2 Antibody

Binding Specificity: C-Term

Sequence: QEESTPQSDV TEDGESPEDP SGTEGQLSEE EKPDQQPLSG EEELEPEAS

Predicted Reactivity: Cow: 86%, Dog: 86%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against BSCL2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human BSCL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 462 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BSCL2

Target: BSCL2 (Berardinelli-Seip Congenital Lipodystrophy 2 (Seipin) (BSCL2))

Alternative Name: BSCL2

Background: This gene encodes protein seipin, which is located in the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: GNG3LG, HMN5, MGC4694, SPG17
Protein Interaction Partner: SMLR1, SMIM3, PLEKHF2, TMEM19, NSG1, SUMO2, SUMO3, Hoxa1, UBC, CANX, USE1,
Protein Size: 462

Molecular Weight: 51 kDa

Gene ID: 26580

NCBI Accession: NM_001122955, NP_001116427

UniProt: Q96G97