HLA-DPA1 antibody (Middle Region)
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- Target See all HLA-DPA1 Antibodies
- HLA-DPA1 (Major Histocompatibility Complex, Class II, DP alpha 1 (HLA-DPA1))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HLA-DPA1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EAQEPIQMPE TTETVLCALG LVLGLVGIIV GTVLIIKSLR SGHDPRAQGT
- Predicted Reactivity
- Human: 100%, Pig: 86%
- Characteristics
- This is a rabbit polyclonal antibody against HLA-DPA1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human HLA-DPA1
- Top Product
- Discover our top product HLA-DPA1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 260 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- HLA-DPA1 (Major Histocompatibility Complex, Class II, DP alpha 1 (HLA-DPA1))
- Alternative Name
- HLA-DPA1 (HLA-DPA1 Products)
- Synonyms
- DP(W3) antibody, DP(W4) antibody, HLA-DP1A antibody, HLADP antibody, HLASB antibody, PLT1 antibody, major histocompatibility complex, class II, DP alpha 1 antibody, HLA-DPA1 antibody
- Background
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The specific function of this protein remains unknown.HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HLA-DP1A, HLADP, HLASB, PLT1, DP(W3), DP(W4)
Protein Interaction Partner: UBC, CD4, HLA-DPB1, CD74,
Protein Size: 260 - Molecular Weight
- 26 kDa
- Gene ID
- 3113
- NCBI Accession
- NM_033554, NP_291032
- UniProt
- P20036
- Pathways
- TCR Signaling, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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