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PDE6A antibody (N-Term)

PDE6A Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio), Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2786520
  • Target See all PDE6A Antibodies
    PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))
    Binding Specificity
    • 7
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    N-Term
    Reactivity
    • 23
    • 9
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio), Rabbit
    Host
    • 23
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 2
    • 2
    • 2
    This PDE6A antibody is un-conjugated
    Application
    • 21
    • 17
    • 9
    • 4
    • 3
    • 3
    • 3
    Western Blotting (WB)
    Sequence
    YRTRNGIAEL ATRLFNVHKD AVLEDCLVMP DQEIVFPLDM GIVGHVAHSK
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against PDE6A. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of human PDE6A
    Top Product
    Discover our top product PDE6A Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))
    Alternative Name
    PDE6A (PDE6A Products)
    Synonyms
    si:bz1d10.3 antibody, si:rp71-1d10.3 antibody, CGPR-A antibody, PDEA antibody, RP43 antibody, Pdea antibody, nmf282 antibody, phosphodiesterase 6A, cGMP-specific, rod, alpha antibody, phosphodiesterase 6A antibody, pde6a antibody, PDE6A antibody, Pde6a antibody
    Background
    This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
    Alias Symbols: PDEA, RP43, CGPR-A
    Protein Size: 779
    Molecular Weight
    85 kDa
    Gene ID
    5145
    NCBI Accession
    NM_000440, NP_000431
    UniProt
    P16499
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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