PIDD antibody (Middle Region)

Catalog No. ABIN2787144

The Rabbit Polyclonal anti-PIDD antibody has been validated for WB. It is suitable to detect PIDD in samples from Human, Rat, Mouse, Guinea Pig, Cow and Dog.

Quick Overview for PIDD antibody (Middle Region) (ABIN2787144)

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Reactivity: Human, Rat, Mouse, Guinea Pig, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIDD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PIDD Antibody

Binding Specificity: Middle Region

Sequence: RRDPEQVLLQ CLPRNKVDAT LRRLLERYRG PEPSDTVEMF EGEEFFAAFE

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against LRDD. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LRDD

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 753 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Alternative Name: LRDD

Background: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: DKFZp434D229, MGC16925, PIDD, LRDD
Protein Interaction Partner: CRADD, CRYAB, MDFI, SOX8, KEAP1, TEAD3, MAFG, AFP, RPAP3, FANCI, SENP3, TRIM32, ANP32B, HAX1, TELO2, NUP93, AIFM1, RFC5, RFC4, PRKDC, PPP6C, POLR2B, POLD1, PCNA, PRDX1, MCM7, ERCC5, ERCC2, DDB1, CASP2, FADD, RIPK1, IKBKG, CCDC85B, EFEMP2, MADD,
Protein Size: 753

Molecular Weight: 83 kDa

Gene ID: 55367

NCBI Accession: NM_018494, NP_060964

Pathways: p53 Signaling, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity