PAI1 antibody (N-Term)

Catalog No. ABIN2787985

The Rabbit Polyclonal anti-PAI1 antibody (ABIN2787985) specifically detects PAI1 in WB. The antibody is reactive with Human, Mouse, Rat, Rabbit, Pig, Dog, Cow and Sheep samples.

Quick Overview for PAI1 antibody (N-Term) (ABIN2787985)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reactivity: Human, Mouse, Rat, Rabbit, Pig, Dog, Cow, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAI1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PAI1 Antibody

Binding Specificity: N-Term

Sequence: VAHLASDFGV RVFQQVAQAS KDRNVVFSPY GVASVLAMLQ LTTGGETQQQ

Predicted Reactivity: Cow: 86%, Dog: 79%, Human: 100%, Mouse: 93%, Pig: 92%, Rabbit: 93%, Rat: 86%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against SERPINE1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SERPINE1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 402 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Alternative Name: SERPINE1

Background: SERPINE1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
Alias Symbols: PAI, PAI-1, PAI1, PLANH1
Protein Interaction Partner: SGTB, UBQLN1, SGTA, NOS2, UBQLN4, PSMB1, PSMA3, UBC, LRP1B, ACTN4, LRP2, VTN, PLAU, MMP3, F2, PLAT, SERPINE1, PLG, KRT18, KLK2, IGFBP5, ORM1, ELANE, LRP1,
Protein Size: 402

Molecular Weight: 43 kDa

Gene ID: 5054

NCBI Accession: NM_000602, NP_000593

UniProt: P05121

Pathways: p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration