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PANK2 antibody (Middle Region)
PANK2
Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Sheep
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PANK2 Antibody
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Target
See all PANK2 Antibodies
PANK2
(Pantothenate Kinase 2 (PANK2))
Binding Specificity
All epitopes for PANK2 antibodies
Middle Region
Reactivity
All reactivities for PANK2 antibodies
Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Sheep
Host
All hosts for PANK2 antibodies
Rabbit
Clonality
All clonalities for PANK2 antibodies
Polyclonal
Conjugate
All conjugates for PANK2 antibodies
This PANK2 antibody is un-conjugated
Application
All applications for PANK2 antibodies
Western Blotting (WB)
Sequence
FGLPGWAVAS SFGNMMSKEK REAVSKEDLA RATLITITNN IGSIARMCAL
Predicted Reactivity
Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 92%, Zebrafish: 100%
Characteristics
This is a rabbit polyclonal antibody against PANK2. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of HUMAN PANK2
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for PANK2
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Target
PANK2
(Pantothenate Kinase 2 (PANK2))
Alternative Name
PANK2 (PANK2 Products )
Synonyms
ATPANK2 antibody, F10M6.180 antibody, F10M6_180 antibody, pantothenate kinase 2 antibody, PANK2 antibody, C20orf48 antibody, HARP antibody, HSS antibody, NBIA1 antibody, PKAN antibody, 4933409I19Rik antibody, AI642621 antibody, pantothenate kinase 2 antibody, pantothenate kinase 2, mitochondrial antibody, ribonuclease A family member 11 (inactive) antibody, PANK2 antibody, Tsp_01576 antibody, LOC100539295 antibody, Pank2 antibody, RNASE11 antibody
Background
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. Protein Interaction Partner: UBC, DHX36, QRICH2, LXN, YWHAQ, VDAC1, RASGRF2, Protein Size: 460
Molecular Weight
50 kDa
Gene ID
80025
Pathways
Ribonucleoside Biosynthetic Process
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