RFC2 antibody (N-Term)

Catalog No. ABIN2788844

Product Details anti-RFC2 Antibody

Target: RFC2 (Replication Factor C (Activator 1) 2, 40kDa (RFC2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Zebrafish (Danio rerio), Guinea Pig, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFC2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: APGSAGHYEL PWVEKYRPVK LNEIVGNEDT VSRLEVFARE GNVPNIIIAG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 77%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against RFC2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 320 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RFC2

Target: RFC2 (Replication Factor C (Activator 1) 2, 40kDa (RFC2))

Alternative Name: RFC2 (RFC2 Products)

Synonyms: 2610008M13Rik antibody, 40kDa antibody, AI326953 antibody, Recc2 antibody, RFC40 antibody, replication factor C subunit 2 antibody, replication factor C (activator 1) 2 antibody, LOC100231971 antibody, RFC2 antibody, Rfc2 antibody

Background: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome.
Alias Symbols: A1, MGC3665, RFC40
Protein Interaction Partner: CEP76, SUMO2, PCNA, UBC, RPA3, RPA2, RPA1, C14orf166, RTCB, LRRFIP1, PRKDC, KRT18, FLII, DDX1, RFC4, PRKAR1A, PAXIP1, MDC1, TP53BP1, ECT2, BRCA1, BARD1, CHTF18, RFC5, RFC3, RFC1, PURA, NEDD8, RAD18, CAND1, COPS5, CUL3, SMARCAD1, MYC, tat, DDX11, CHD1L, PM
Protein Size: 320

Molecular Weight: 35 kDa

Gene ID: 5982

NCBI Accession: NM_002914, NP_002905

UniProt: Q75MT5

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA