GCKR antibody (C-Term)

Catalog No. ABIN2789592

This Rabbit Polyclonal antibody specifically detects GCKR in WB. It exhibits reactivity toward Human and Rat.

Quick Overview for GCKR antibody (C-Term) (ABIN2789592)

Target: GCKR (Glucokinase (Hexokinase 4) Regulator (GCKR))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCKR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GCKR Antibody

Binding Specificity: C-Term

Sequence: PIALLSLLFR CSITEAQAHL AAAPSVCEAV RSALAGPGQK RTADPLEILE

Predicted Reactivity: Human: 100%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against GCKR. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 625 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GCKR

Target: GCKR (Glucokinase (Hexokinase 4) Regulator (GCKR))

Alternative Name: GCKR

Background: This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
Alias Symbols: GKRP, FGQTL5
Protein Interaction Partner: CDKN1A, UBC, TRAF2, GCK,
Protein Size: 625

Molecular Weight: 68 kDa

Gene ID: 2646

NCBI Accession: NM_001486, NP_001477

UniProt: Q14397

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus