Transferrin Receptor antibody (N-Term)

Catalog No. ABIN2789600

Product Details anti-Transferrin Receptor Antibody

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Binding Specificity: N-Term

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PVREEPGEDF PAARRLYWDD LKRKLSEKLD STDFTGTIKL LNENSYVPRE

Predicted Reactivity: Human: 100%, Rabbit: 91%

Characteristics: This is a rabbit polyclonal antibody against TFRC. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 760 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: TFRC (TFRC Products)

Synonyms: Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody

Background: TFRC is a cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Alias Symbols: CD71, TFR, TFR1, TRFR, T9, TR, p90
Protein Interaction Partner: HUWE1, UBC, SGTA, CAV1, TP53, RAB8A, RANBP9, LGR4, MDM2, RPA3, RPA2, RPA1, ASB4, RNF2, OPTN, ADRB2, CLN3, MARCH8, env, MARCH1, MYO1G, VCAM1, ITGA4, FN1, ATF2, B4GALT1, ESR1, ATP6V1B1, FBXO6, KCNA5, KCNA3, vpu, SH3BP4, PARK2, LAPTM4B, LAPTM4A, HGS, SUMO2,
Protein Size: 760

Molecular Weight: 84 kDa

Gene ID: 7037

NCBI Accession: NM_003234, NP_003225

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis