Ephrin B3 antibody (C-Term)

Catalog No. ABIN2789618

Product Details anti-Ephrin B3 Antibody

Target: Ephrin B3 (EFNB3)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ephrin B3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AGAGGAMCWR RRRAKPSESR HPGPGSFGRG GSLGLGGGGG MGPREAEPGE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Efnb3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Efnb3

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Ephrin B3

Target: Ephrin B3 (EFNB3)

Alternative Name: Efnb3 (EFNB3 Products)

Synonyms: efnb3-A antibody, EphB3 antibody, EFNB3 antibody, efnb3 antibody, id:ibd5049 antibody, zgc:111938 antibody, EFL-6 antibody, ELF-3 antibody, Elk-L3 antibody, Epl8 antibody, LERK-8 antibody, NLERK-2 antibody, ELK-L3 antibody, RGD1565678 antibody, EFL6 antibody, EPLG8 antibody, LERK8 antibody, ephrin B3 antibody, ephrin-B3 L homeolog antibody, ephrin-B3b antibody, ephrin-B3 antibody, EFNB3 antibody, efnb3.L antibody, efnb3b antibody, efnb3 antibody, Efnb3 antibody

Background: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Efnb3 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. It may play a pivotal role in forebrain function. It binds to, and induce the collapse of, commissural axons/growth cones in vitro. Efnb3 may play a role in constraining the orientation of longitudinally projecting axons.
Alias Symbols: EFL-6, ELF-3, Elk-L3, Epl8, LERK-8, NLERK-2
Protein Size: 340

Molecular Weight: 36 kDa

Gene ID: 13643

NCBI Accession: NM_007911, NP_031937

UniProt: O35393

Pathways: RTK Signaling