CPI-17 antibody (N-Term)

Catalog No. ABIN2789677

Product Details anti-CPI-17 Antibody

Target: CPI-17 (PPP1R14A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Pig, Cow, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPI-17 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GKRVLSKLQS PSRARGPGGS PGGLQKRHAR VTVKYDRREL QRRLDVEKWI

Predicted Reactivity: Cow: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against PPP1R14A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 147 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CPI-17 antibody (ABIN2789677)

Xiong, Xia, Tang, Pan, Mei, Xiong: "Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response." in: EBioMedicine, Vol. 9, pp. 45-60, (2016) (PubMed).

Target Details for CPI-17

Target: CPI-17 (PPP1R14A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A))

Alternative Name: PPP1R14A (PPP1R14A Products)

Synonyms: MGC81874 antibody, cpi-17 antibody, ppp1inl antibody, CPI-17 antibody, im:7147597 antibody, ppp1r14a antibody, zgc:110700 antibody, PPP1R14A antibody, CPI17 antibody, PPP1INL antibody, Cpi17 antibody, 1110001M11Rik antibody, protein phosphatase 1 regulatory inhibitor subunit 14A L homeolog antibody, protein phosphatase 1 regulatory inhibitor subunit 14A antibody, protein phosphatase 1, regulatory (inhibitor) subunit 14Aa antibody, protein phosphatase 1, regulatory (inhibitor) subunit 14A antibody, ppp1r14a.L antibody, ppp1r14a antibody, ppp1r14aa antibody, PPP1R14A antibody, Ppp1r14a antibody

Background: The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Alias Symbols: CPI-17, CPI17, PPP1INL
Protein Interaction Partner: cki1, CSNK1G1, YWHAZ, PRKCZ, PRKD1, PRKCH, PRKCE, PRKCA, CSNK1G3, CSNK1G2, CSNK1E, CSNK1D, CSNK1A1, APP, PRNP, UBC, PRKCG,
Protein Size: 147

Molecular Weight: 17 kDa

Gene ID: 94274

NCBI Accession: NM_033256, NP_150281

UniProt: Q96A00