Sortilin 1 antibody (C-Term)

Catalog No. ABIN2789904

Product Details anti-Sortilin 1 Antibody

Target: Sortilin 1 (SORT1)

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sortilin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: YVCGGRFLVH RYSVLQQHAE ANGVDGVDAL DTASHTNKSG YHDDSDEDLL

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SORT1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 831 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Sortilin 1

Target: Sortilin 1 (SORT1)

Alternative Name: SORT1 (SORT1 Products)

Synonyms: SORT1 antibody, 19.m02079 antibody, gp95 antibody, ldlcq6 antibody, sortilin antibody, Gp95 antibody, LDLCQ6 antibody, NT3 antibody, 2900053A11Rik antibody, AI852375 antibody, Ntr3 antibody, Ntsr3 antibody, Nt3 antibody, Nts3 antibody, sort1 antibody, zgc:85953 antibody, sortilin 1 antibody, sortilin antibody, sortilin 1 S homeolog antibody, sortilin 1a antibody, SORT1 antibody, TP01_0016 antibody, BBOV_I002730 antibody, sort1.S antibody, Sort1 antibody, sort1a antibody

Background: This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes, however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p, the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
Alias Symbols: Gp95, NT3
Protein Interaction Partner: NUDCD3, UBC, SORCS1, GGA1, GGA3, GGA2, STAM, ELAVL1, NTS, NGF, NGFR, BDNF, LRPAP1, CDK2, SLC2A4,
Protein Size: 831

Molecular Weight: 84 kDa

Gene ID: 6272

NCBI Accession: NM_002959, NP_002950

UniProt: Q99523

Pathways: Neurotrophin Signaling Pathway