MYSM1 antibody (N-Term)
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- Target See all MYSM1 Antibodies
- MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
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Binding Specificity
- N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MYSM1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- KLIGSRTVLQ VKSYARQYFK NKVKCGLDKE TPNQKTGHNL QVKNEDKGTK
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MYSM1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human MYSM1
- Top Product
- Discover our top product MYSM1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 828 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
- Alternative Name
- MYSM1 (MYSM1 Products)
- Synonyms
- 2A-DUB antibody, 2ADUB antibody, RP4-592A1.1 antibody, C130067A03Rik antibody, C530050H10Rik antibody, RGD1311787 antibody, 2adub antibody, Myb like, SWIRM and MPN domains 1 antibody, myb-like, SWIRM and MPN domains 1 antibody, Myb like, SWIRM and MPN domains 1 L homeolog antibody, MYSM1 antibody, Mysm1 antibody, mysm1.L antibody
- Background
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MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Alias Symbols: 2A-DUB, 2ADUB, DKFZp779J1554, DKFZp779J1721, KIAA1915, RP4-592A1.1
Protein Interaction Partner: UBC, DICER1, SUMO2, TUBB1, WDR77, STK38, PRMT5, KAT2B, HIST2H2AC, RBM10, KIF11, HSPA1A, HNRNPH1, EEF1A1,
Protein Size: 828 - Molecular Weight
- 91 kDa
- Gene ID
- 114803
- NCBI Accession
- NM_001085487, NP_001078956
- UniProt
- Q5VVJ2
- Pathways
- Chromatin Binding
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