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Insulin Receptor antibody (INSR) (Middle Region) Primary Antibody

INSR Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio) IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792204
$389.00
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100 μL
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  • Target
    Insulin Receptor (INSR)
    Binding Specificity
    • 26
    • 18
    • 16
    • 12
    • 12
    • 10
    • 10
    • 9
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 204
    • 109
    • 86
    • 19
    • 17
    • 16
    • 16
    • 14
    • 13
    • 8
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)
    Host
    • 178
    • 45
    • 3
    • 1
    Rabbit
    Clonality
    • 173
    • 54
    Polyclonal
    Conjugate
    • 130
    • 21
    • 16
    • 11
    • 8
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Insulin Receptor antibody is un-conjugated
    Application
    • 142
    • 103
    • 68
    • 38
    • 25
    • 20
    • 13
    • 13
    • 10
    • 10
    • 9
    • 9
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Sequence
    SSHCQREEAG GRDGGSSLGF KRSYEEHIPY THMNGGKKNG RILTLPRSNP
    Predicted Reactivity
    Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 93%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against INSR. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human INSR
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1382 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Insulin Receptor (INSR)
    Alternative Name
    INSR (INSR Antibody Abstract)
    Synonyms
    CD220, HHF5, 4932439J01Rik, D630014A15Rik, IR, IR-A, IR-B, 18402, CG18402, DIHR, DILR, DIR, DIRH, DIRbeta, DInR, DInr, Dir-a, Dir-b, Dmel\\CG18402, INR, INS, Inr, Inr-alpha, Inr-beta, InsR, dINR, dIR, dIRH, dInR, dInr, dInsR, dinr, dir, er10, inr, insulin/insulin-like growth factor receptor, l(3)05545, l(3)93Dj, l(3)er10, lnR, ir-A, CTK-1, ir, INSR, NV14476, cd220, hhf5, insulin receptor, Insulin-like receptor, insulin receptor L homeolog, INSR, Insr, InR, LOC100122567, LOC100451802, insr.L
    Background
    This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1.A report shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, another report shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: CD220, HHF5
    Protein Interaction Partner: KRT31, UBC, ARRB2, MOK, Grb2, Hgf, DOK1, SH2B1, Stat5b, TEAD1, STAT5A, JAK2, JAK1, IRS1, IRF7, PLCG1, GRB10, Socs6, Socs1, SOCS3, SH2B2, HGS, INPPL1, Calmodulin, Mad2l1, KRT27, DOK5, DOK4, SNX6, SNX4, SNX2, ACP1, PTPN2, SYNCRIP, FRS2, PIK3R3, VAV3, ARHGAP
    Protein Size: 1382
    Molecular Weight
    154 kDa
    Gene ID
    3643
    NCBI Accession
    NM_000208, NP_000199
    UniProt
    P06213
    Pathways
    NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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