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Growth Hormone Receptor antibody

GHR Reactivity: Human IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2854312
  • Target See all Growth Hormone Receptor (GHR) Antibodies
    Growth Hormone Receptor (GHR)
    Reactivity
    • 52
    • 32
    • 32
    • 17
    • 16
    • 2
    • 1
    Human
    Host
    • 51
    • 4
    Rabbit
    Clonality
    • 43
    • 12
    Polyclonal
    Conjugate
    • 24
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Growth Hormone Receptor antibody is un-conjugated
    Application
    • 37
    • 19
    • 15
    • 14
    • 14
    • 6
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Characteristics
    Rabbit Polyclonal antibody to Growth hormone Receptor (growth hormone receptor)
    Growth hormone Receptor antibody [N3C2], Internal
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human Growth hormone Receptor. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product GHR Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.7 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    Growth Hormone Receptor (GHR)
    Alternative Name
    growth hormone receptor (GHR Products)
    Synonyms
    GHBP antibody, AA986417 antibody, GHR/BP antibody, GHR antibody, ghr antibody, ghr.a antibody, zgc:162141 antibody, growth hormone receptor antibody, growth hormone receptor L homeolog antibody, growth hormone receptor a antibody, GHR antibody, Ghr antibody, ghr.L antibody, ghr antibody, ghra antibody
    Background
    This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein.

    Cellular Localization: Cell membrane, Single-pass type I membrane protein , Isoform 2: Cell membrane, Single-pass type I membrane protein , Growth hormone-binding protein: Secreted
    Molecular Weight
    72 kDa
    Gene ID
    2690
    UniProt
    P10912
    Pathways
    NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus
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