Lamin A/C antibody (LMNA) (Center)

Details for Product anti-LMNA Antibody No. ABIN2854942, Supplier: Log in to see
Antigen
  • 2459
  • 74/76
  • CG6944
  • D5
  • DM[[O]]
  • Dm
  • Dm(0)
  • Dm0
  • Dm1
  • Dm2
  • DmLamin
  • DmO
  • Dm[[0]]
  • Dm[[1]]
  • Dm[[2]]
  • Dm[[mit]]
  • Dm[[o]]
  • Dmel\\CG6944
  • Dmo
  • LAM
  • Lam Dm[[0]]
  • Lam(Dm0)
  • LamDm[[0]]
  • LamDm[[o]]
  • Lam[[Dm0]]
  • Lamin Dm[[0]]
  • jf27
  • l(2)04643
  • l(2)25Ec
  • l(2)gdh-7
  • l(2)gdh7
  • l(2)jf27
  • lam
  • lamDm0
  • lamDm[[0]]
  • lamin
  • lamin Dm0
  • lamin Dm[[0]]
  • misg
  • nlam
  • cb948
  • fk66d12
  • wu:fk66d12
  • fpl
  • idc
  • lfp
  • cddc
  • emd2
  • fpld
  • hgps
  • ldp1
  • lmn1
  • lmnc
  • pro1
  • cdcd1
  • cmd1a
  • cmt2b1
  • lgmd1b
  • Lamin-A
  • Dhe
  • CDCD1
  • CDDC
  • CMD1A
  • CMT2B1
  • EMD2
  • FPL
  • FPLD
  • FPLD2
  • HGPS
  • IDC
  • LDP1
  • LFP
  • LGMD1B
  • LMN1
  • LMNC
  • LMNL1
  • PRO1
  • lmna-A
  • lamin-L(III)-like
  • Lamin
  • lamin A
  • lamin A/C
  • lamin B3
  • lamin A/C L homeolog
  • lamin-L(III)-like
  • Lam
  • lmna
  • LMNA
  • lmnb3
  • Lmna
  • lmna.L
  • LMINA
Alternatives
anti-Mouse (Murine) Lamin A/C antibody for Western Blotting
Epitope
Center
34
26
23
21
18
16
15
14
12
9
9
9
8
7
6
4
4
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
418
257
224
102
53
51
22
19
15
10
8
7
5
5
3
3
2
1
1
1
Host
Rabbit
210
207
5
1
Clonality
Polyclonal
Conjugate
This Lamin A/C antibody is un-conjugated
11
11
9
7
7
6
6
6
6
6
6
6
6
6
5
5
4
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
385
194
155
155
107
104
72
65
47
14
11
9
2
2
1
1
Options
Supplier
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Immunogen Recombinant protein encompassing a sequence within the center region of human Lamin A/C. The exact sequence is proprietary.
Isotype IgG
Characteristics Rabbit Polyclonal antibody to Lamin A + C
Lamin A + C antibody
Purification Purified by antigen-affinity chromatography.
Alternative Name Lamin A + C (LMNA Antibody Abstract)
Background The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Cellular Localization: Nucleus
Molecular Weight 74 kDa
Gene ID 4000
Pathways Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
Application Notes Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Immunoprecipitation 1:66-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Immunoprecipitation1:66-1:500* Western blot1:500-1:3000*
Comment

Positive Control: HeLa nucleus , C2C12 , NIH-3T3

Restrictions For Research Use only
Format Liquid
Concentration 0.27 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) IHC-P Image Lamin A + C antibody detects Lamin A + C protein at nuclear envelope on m...
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) IHC-P Image Lamin A + C antibody detects Lamin A + C protein at nuclear envelope on m...
Western Blotting (WB) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) WB Image Whole cell extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane ...
Immunofluorescence (IF) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed H...
Western Blotting (WB) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) WB Image Lamin A + C antibody detects Lamin A + C protein by Western blot analysis. A...
Immunoprecipitation (IP) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) IP Image Immunoprecipitation of Lamin A + C protein from HeLa whole cell extracts usi...
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) IHC-P Image Lamin A + C antibody detects Lamin A + C protein at nuclear envelope on m...
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) IHC-P Image Lamin A + C antibody detects Lamin A + C protein at membrane on U87 xenog...
Western Blotting (WB) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) WB Image Lamin A + C antibody detects Lamin A + C protein by Western blot analysis. A...
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (Center) antibody (ABIN2854942) IHC-P Image Lamin A + C antibody detects Lamin A + C protein at nuclear envelope on h...
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