ALDH2 antibody (N-Term)

Catalog No. ABIN3029896

Product Details anti-ALDH2 Antibody

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Binding Specificity: N-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALDH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human Aldehyde Dehydrogenase 2 (SAAATQAVPAPNQQPE) was used as the immunogen for this ALDH2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the ALDH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the ALDH2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for ALDH2

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Alternative Name: ALDH2 (ALDH2 Products)

Synonyms: aldh2 antibody, aldh2a antibody, zgc:63786 antibody, MGC80785 antibody, aldh-e2 antibody, aldhi antibody, aldm antibody, rf2b antibody, ALDH-E2 antibody, ALDHI antibody, ALDM antibody, Ahd-5 antibody, Ahd5 antibody, aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 antibody, aldehyde dehydrogenase 2 family (mitochondrial) L homeolog antibody, aldehyde dehydrogenase 2 family (mitochondrial) antibody, aldehyde dehydrogenase 2 antibody, aldehyde dehydrogenase antibody, aldehyde dehydrogenase (NAD(+)) antibody, hypothetical protein antibody, aldehyde dehydrogenase 2, mitochondrial antibody, aldh2.1 antibody, aldh2.L antibody, aldh2 antibody, ALDH2 antibody, RHA1_RS43090 antibody, aldH2 antibody, OE_RS03015 antibody, Aldh2 antibody

Background: Aldehyde Dehydrogenase 2 is a human gene. The enzyme encoded by this gene belongs to the ALDH family of enzymes that catalyze the chemical transformation from acetaldehyde to acetic acid. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Hsu et al.(1985) assigned the ALDH2 locus to chromosome 12 by means of a cDNA probe and Southern blot analysis of somatic cell hybrids. Using an unbiased proteomic search, Chen et al.(2008) identified mitochondrial ALDH2 as an enzyme whose activation correlated with reduced ischemic heart damage in rodent models. A high-throughput screen identified a small molecule activator of ALDH2, which they called Alda-1, that, when administered to rats before an ischemic event, reduced infarct size by 60 % , most likely through its inhibitory effect on the formation of cytotoxic aldehydes.

UniProt: P05091