Cyclin A1 antibody

Catalog No. ABIN303074

Product Details anti-Cyclin A1 Antibody

Target: Cyclin A1 (CCNA1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to full length synthetic polypeptide corresponding to the human gene sequence.

Purification: Delipidation and defibrination

Application Details

Application Notes: Immunoprecipitation. Immunofluorescence. Immunohistochemistry on paraffin sections: 1: 500. Western Blot. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for Cyclin A1

Target: Cyclin A1 (CCNA1)

Alternative Name: Cyclin A1 (CCNA1 Products)

Synonyms: fd14f08 antibody, wu:fd14f08 antibody, wu:fi20d12 antibody, zgc:111869 antibody, MGC81965 antibody, cyclin-A1 antibody, CCNA1 antibody, MGC132235 antibody, cyclin-A1-2 antibody, Cyclin-A1 antibody, ccna1 antibody, cyclin A1 antibody, cyclin A1 L homeolog antibody, CYCLIN A1;2 antibody, cyclin A1 S homeolog antibody, CCNA1 antibody, ccna1 antibody, ccna1.L antibody, CYCA1;2 antibody, Ccna1 antibody, ccna1.S antibody

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Synonyms: CCNA1, Cyclin-A1

Gene ID: 8900

NCBI Accession: NP_001104515

UniProt: P78396

Pathways: Apoptosis, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA