FURIN antibody (AA 591-794)

Catalog No. ABIN3031005

Product Details anti-FURIN Antibody

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Binding Specificity: AA 591-794

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FURIN antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 591-794) was used as the immunogen for this Furin antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Furin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Furin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for FURIN

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Alternative Name: Furin (FURIN Products)

Synonyms: FURIN antibody, furin antibody, si:dkey-281a24.5 antibody, FUR antibody, LOC100220259 antibody, PACE antibody, spc1 antibody, xfurin antibody, MGC82710 antibody, PCSK3 antibody, SPC1 antibody, 9130404I01Rik antibody, Fur antibody, Pcsk3 antibody, Pace antibody, furin, paired basic amino acid cleaving enzyme antibody, furin (paired basic amino acid cleaving enzyme) a antibody, furin (paired basic amino acid cleaving enzyme) b antibody, furin, paired basic amino acid cleaving enzyme L homeolog antibody, furin (paired basic amino acid cleaving enzyme) antibody, FURIN antibody, furina antibody, furinb antibody, furin antibody, furin.L antibody, Furin antibody

Background: Furin (Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. Furin is thought to play a role in tumor progression. It is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression in T-cells is required for maintenance of peripheral immune tolerance.

Gene ID: 5045

Pathways: Notch Signaling, Neurotrophin Signaling Pathway