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IL4 Receptor antibody (Middle Region)

IL4R Reactivity: Human IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031482
$635.25
Plus shipping costs $45.00
100 μg
Shipping to: United States
Delivery in 2 to 3 Business Days
  • Target See all IL4 Receptor (IL4R) Antibodies
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    Binding Specificity
    • 15
    • 15
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 42
    • 33
    • 20
    Human
    Host
    • 62
    • 2
    Rabbit
    Clonality
    • 62
    • 2
    Polyclonal
    Conjugate
    • 29
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IL4 Receptor antibody is un-conjugated
    Application
    • 35
    • 17
    • 15
    • 13
    • 13
    • 12
    • 8
    • 5
    • 5
    • 4
    • 3
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogen
    An amino acid sequence from the middle region of human IL4R (TKWHNSYREPFEQH) was used as the immunogen for this IL4R antibody.
    Isotype
    IgG
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the IL4R antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the IL4R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    Alternative Name
    IL4R (IL4R Products)
    Synonyms
    IL4R antibody, il-4ra antibody, zgc:113063 antibody, CD124 antibody, IL-4RA antibody, IL4RA antibody, Il4ra antibody, IL4 antibody, Il4r antibody, interleukin 4 receptor antibody, interleukin 4 receptor, tandem duplicate 1 antibody, interleukin 4 receptor, alpha antibody, IL4R antibody, il4r.1 antibody, Il4r antibody, Il4ra antibody
    Background
    IL4R (Interleukin 4 receptor) is a human gene that encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. The gene is localized to 16p12.1-p11.2 by in situ hybridization and Southern blot analysis of DNA from a panel of mouse-human somatic cell lines. IL4 plays a major role in immunoglobulin E(IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL4 receptor. IL4 interacts with IL4R with high affinity, leading to dimerization with either the common gamma chain,a component of receptors for a number of cytokines, to create a type I receptor, or with IL13RA1 to form a type II receptor. The IL4R gene contains 12 exons and the protein is a complex of at least two components, one of which is a novel affinity converting subunit that is critical for cellular signal transduction.
    UniProt
    P24394
    Pathways
    JAK-STAT Signaling, Positive Regulation of Immune Effector Process
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