Midkine antibody (AA 21-143)

Catalog No. ABIN3031798

Product Details anti-Midkine Antibody

Target: Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))

Binding Specificity: AA 21-143

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Midkine antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 21-143) was used as the immunogen for this Midkine antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Midkine antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Midkine antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Midkine

Target: Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))

Alternative Name: Midkine (MDK Products)

Synonyms: ARAP antibody, MK antibody, NEGF2 antibody, Mek antibody, MK-B antibody, PTF-alpha-1 antibody, mdk antibody, midkine antibody, negf2 antibody, RIHB antibody, cb518 antibody, fb79b05 antibody, fj33b02 antibody, fj48a12 antibody, mdk2 antibody, plei2 antibody, wu:fb79b05 antibody, wu:fj33b02 antibody, wu:fj48a12 antibody, MK-A antibody, PTF-alpha-2 antibody, X-PTF-alpha1 antibody, XMK antibody, mdk-a antibody, mdk-b antibody, midkine antibody, midkine L homeolog antibody, midkine (neurite growth-promoting factor 2) antibody, midkine b antibody, midkine S homeolog antibody, MDK antibody, Mdk antibody, mdk.L antibody, mdkb antibody, mdk.S antibody

Background: Midkine(MK or MDK), also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene. Midkine is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin(NEGF1, 46 % homologous with MK). It is a nonglycosylated protein, composed of two domains held by disulfide bridges. It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation, hence the name midkine. Restricted mainly to certain tissues in the normal adult, it is strongly induced during oncogenesis, inflammation and tissue repair. Midkine is pleiotropic, capable of exerting activities such as cell proliferation, cell migration, angiogenesis and fibrinolysis. A molecular complex containing receptor-type tyrosine phosphatase zeta, low density lipoprotein receptor-related protein (LRP1), anaplastic leukemia kinase (ALK) and syndecans is considered to be its receptor.

Gene ID: 4192

Pathways: RTK Signaling, M Phase, Skeletal Muscle Fiber Development