SIRT2 antibody (AA 165-187)

Catalog No. ABIN3032588

Product Details anti-SIRT2 Antibody

Target: SIRT2 (Sirtuin 2 (SIRT2))

Binding Specificity: AA 165-187

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Amino acids 165-187 (YTQNIDTLERIAGLEQEDLVEAH-human) were used as the immunogen for this SIRT2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the SIRT2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SIRT2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Alternative Name: SIRT2 (SIRT2 Products)

Synonyms: CG5085 antibody, D.mel2 antibody, Dmel\\CG5085 antibody, SIRT2 antibody, dSIRT2 antibody, sir2 antibody, Sirt2 antibody, BmSirt2 antibody, AtSRT2 antibody, SIRTUIN 2 antibody, T2K12.8 antibody, sirtuin 2 antibody, SIR2 antibody, SIR2L antibody, SIR2L2 antibody, 5730427M03Rik antibody, Sir2l antibody, wu:fb57d05 antibody, zgc:55966 antibody, zgc:77003 antibody, Sirtuin 2 antibody, sirtuin 2 antibody, sirtuin 2 S homeolog antibody, NAD-dependent deacetylase sirtuin 2 homolog antibody, sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) antibody, Sirt2 antibody, SIRT2 antibody, sirt2.S antibody, SRT2 antibody, sirt2 antibody

Background: Sirtuin 2 is a predominantly cytoplasmic protein that colocalizes with microtubules. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT2 is mapped to 19q13.2. It is able to cause radioactivity to be transferred from (32P) NAD to bovine serum albumin (BSA). According to researches, it can act as a tubulin deacetylase. SIRT2 was found to deacetylate lys40 of alpha-tubulin both in vitro and in vivo. It is also a regulator of mitotic progression that acts downstream from CDC14B in a pathway regulating mitotic exit or subsequent cytokinesis. Additionally, SIRT2 is an important regulator of programmed necrosis.

Gene ID: 22933