LILRB1 antibody

Catalog No. ABIN316937

Product Details anti-LILRB1 Antibody

Target: LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LILRB1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody is specific for CD85j, a member of the leukocyte immunoglobulin-like receptor (LIR) family.

Characteristics: Synonyms: LIR-3, ILT5, LIR3, HL9, Leukocyte immunoglobulin-like receptor subfamily B member 3,Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyteinhibitory receptor HL9, CD85 antigen-like family member A

Purification: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Monocyte derived dendritic cells

Clone: 4F9

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry: 1/50 - 1/200. Immunohistochemistry on frozen sections: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only.

Expiry Date: 12 months

Target Details for LILRB1

Target: LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))

Alternative Name: CD85j / LILRB1 (LILRB1 Products)

Synonyms: CD85J antibody, ILT-2 antibody, ILT2 antibody, LIR-1 antibody, LIR1 antibody, MIR-7 antibody, MIR7 antibody, leukocyte immunoglobulin like receptor B1 antibody, LILRB1 antibody

Background: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. CD85j is a receptor for MHC Class I molecules and ligand binding results in inhibitory signals and down-regulation of the immune response.CD85j is expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells, T-cells and natural killer (NK) cells.Synonyms: CD85 antigen-like family member J, ILT-2, ILT2, Immunoglobulin-like transcript 2, LILR-B1, LIR-1, LIR1, Leukocyte immunoglobulin-like receptor 1, Leukocyte immunoglobulin-like receptor subfamily B member 1, MIR-7, MIR7, Monocyte/macrophage immunoglobulin-like receptor 7

Gene ID: 10859

UniProt: O75022

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response