CLCN6 antibody

Catalog No. ABIN317827

Product Details anti-CLCN6 Antibody

Target: CLCN6 (Chloride Channel, Voltage-Sensitive 6 (CLCN6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCN6 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: CLC-6 antibody detects endogenous levels of CLC-6 protein.(region surrounding Lys649)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CLCN6

Target: CLCN6 (Chloride Channel, Voltage-Sensitive 6 (CLCN6))

Alternative Name: CLCN6 (CLCN6 Products)

Synonyms: CLC-6 antibody, AI850629 antibody, CLCN6 antibody, wu:fb95f01 antibody, DKFZp469B244 antibody, DKFZp469L0417 antibody, chloride voltage-gated channel 6 antibody, chloride channel, voltage-sensitive 6 antibody, chloride channel 6 antibody, chloride transport protein 6 antibody, CLCN6 antibody, Clcn6 antibody, clcn6 antibody, LOC579870 antibody

Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.Synonyms: Chloride channel protein 6, Chloride transport protein 6, ClC-6, ClC6, KIAA0046

Molecular Weight: approx. 90 kDa

Gene ID: 1185

NCBI Accession: NP_001277

UniProt: P51797