PPP1R3C antibody

Catalog No. ABIN317934

Product Details anti-PPP1R3C Antibody

Target: PPP1R3C (Protein Phosphatase 1, Regulatory Subunit 3C (PPP1R3C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R3C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of PTG protein.(region surrounding Lys75)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PPP1R3C

Target: PPP1R3C (Protein Phosphatase 1, Regulatory Subunit 3C (PPP1R3C))

Alternative Name: PPP1R3C / PTG (PPP1R3C Products)

Synonyms: PPP1R5 antibody, PTG antibody, Ppp1r5 antibody, R5 antibody, ppp1r3c antibody, zgc:73259 antibody, cb444 antibody, fc19f02 antibody, sb:cb444 antibody, wu:fb50a11 antibody, wu:fc17c07 antibody, wu:fc19f02 antibody, zgc:92069 antibody, protein phosphatase 1 regulatory subunit 3C antibody, protein phosphatase 1, regulatory (inhibitor) subunit 3C antibody, protein phosphatase 1, regulatory subunit 3C antibody, protein phosphatase 1, regulatory subunit 3Cb antibody, protein phosphatase 1, regulatory subunit 3Ca antibody, PPP1R3C antibody, Ppp1r3c antibody, ppp1r3cb antibody, ppp1r3c antibody, ppp1r3ca antibody

Background: Protein phosphatase 1 (PP1) is a serine-threonine protein phosphatase that plays a central role in mediating the effects of insulin on glucose and lipid metabolism. PTG (protein targeting to glycogen) was cloned from 3T3-L1 adipocytes as a protein that binds to the PP1 catalytic subunit. The human homolog of PTG, designated PPP1R5, has been shown to bind to PP1 and to modulate its specificity. PTEN/PPP1R5 shows 42 % identity to the glycogen binding subunit, G(L), of rat liver PP1. PTG is expressed predominantly in insulin-sensitive tissues, and it localizes PP1 to glycogen. PTG also has been shown to interact with several enzymes involved in the hormonal regulation of glycogen metabolism, including phosphorylase kinase, phosphorylase A and glycogen synthase. These data indicate a role for PTG in glycogen metabolism, possibly that of a molecular scaffold.Synonyms: PPP1R5, Protein phosphatase 1 regulatory subunit 3C, Protein phosphatase 1 regulatory subunit 5, Protein targeting to glycogen

Molecular Weight: approx. 36 kDa

Gene ID: 5507

NCBI Accession: NP_005389

UniProt: Q9UQK1

Pathways: Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process