PPP1R3C
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Protein phosphatase 1 (PP1) is a serine-threonine protein phosphatase that plays a central role in mediating the effects of insulin on glucose and lipid metabolism. PTG (protein targeting to glycogen) was cloned from 3T3-L1 adipocytes as a protein that binds to the PP1 catalytic subunit. The human homolog of PTG, designated PPP1R5, has been shown to bind to PP1 and to modulate its specificity. PTEN/PPP1R5 shows 42 % identity to the glycogen binding subunit, G(L), of rat liver PP1. PTG is expressed predominantly in insulin-sensitive tissues, and it localizes PP1 to glycogen. PTG also has been shown to interact with several enzymes involved in the hormonal regulation of glycogen metabolism, including phosphorylase kinase, phosphorylase A and glycogen synthase. These data indicate a role for PTG in glycogen metabolism, possibly that of a molecular scaffold.Synonyms: PPP1R5, Protein phosphatase 1 regulatory subunit 3C, Protein phosphatase 1 regulatory subunit 5, Protein targeting to glycogen