10C2 reacts exclusively with the human nestin protein. No cross-reactivity to rodent nestin.
Purification
Purified
Immunogen
Nestin (clone 10C2) is a monoclonal antibody derived by traditional hybridoma technology. A 150-amino-acid fragment from the cloned human nestin was conjugated to glutathione S-transferase and used as an immunogen.
NES
Reactivity: Human
IF, ICC
Host: Mouse
Monoclonal
10C2
FITC
Restrictions
For Research Use only
Storage
-20 °C
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Mokry, Pudil, Ehrmann, Cizkova, Osterreicher, Filip, Kolar: "Re-expression of nestin in the myocardium of postinfarcted patients." in: Virchows Archiv : an international journal of pathology, Vol. 453, Issue 1, pp. 33-41, (2008) (PubMed).
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paranemin antibody, NES antibody, AA166324 antibody, C78523 antibody, ESTM46 antibody, nestin antibody, nestin S homeolog antibody, NES antibody, nes.S antibody, Nes antibody, nes antibody
Background
Nestin is a Class IV intermediate filament protein abundantly produced in the developing central nervous system (CNS) and in early embryonic neuroepithelial stem cells. This cytoskeletal protein has been widely used as a predominant marker for stem/progenitor cells, glioma cells, and tumor endothelial cells. Also, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumors. These highly specific antibodies to human nestin can aid in characterizing progenitor cells differentiating into distinct lineages, in enhancing the therapeutic potential of human neural stem/progenitor cells in the treatment of CNS diseases or injury, and in identifying neuroepithelial tumor cells.