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ERN2 antibody (N-Term)
ERN2
Reactivity: Human, Mouse
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ERN2 Antibody
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Target
See all ERN2 Antibodies
ERN2
(Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))
Binding Specificity
All epitopes for ERN2 antibodies
N-Term
Reactivity
Human, Mouse
Host
All hosts for ERN2 antibodies
Rabbit
Clonality
All clonalities for ERN2 antibodies
Polyclonal
Conjugate
All conjugates for ERN2 antibodies
This ERN2 antibody is un-conjugated
Application
All applications for ERN2 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody reacts to ERN2 / IRE2.
Purification
Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Immunogen
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ERN2.
Isotype
Ig Fraction
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Discover our top product ERN2 Primary Antibody
Alternatives
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Application Details
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Application Notes
ELISA: 1/1,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Target Details for ERN2
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Target
ERN2
(Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))
Abstract
ERN2 Products
Synonyms
Ire1beta antibody, ire1b antibody, Ern1 antibody, Ire1 antibody, Ire1b antibody, IRE1-BETA antibody, IRE1b antibody, endoplasmic reticulum to nucleus signaling 2 antibody, endoplasmic reticulum (ER) to nucleus signalling 2 antibody, ERN2 antibody, ern2 antibody, Ern2 antibody
Background
ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.Synonyms: Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, Ire1-beta, Serine/threonine-protein kinase/endoribonuclease IRE2
Gene ID
10595, 9606
UniProt
Q76MJ5
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