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SMAD3 antibody (SMAD, Mothers Against DPP Homolog 3) (AA 423-427) Primary Antibody

SMAD3 Reactivity: Human, Mouse, Rat IF, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN363049
$207.90
Plus shipping costs $45.00
50 μL ABIN363049
50 μL ABIN363049
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days
  • Target
    SMAD3
    Binding Specificity
    • 33
    • 30
    • 29
    • 29
    • 21
    • 16
    • 13
    • 11
    • 11
    • 11
    • 10
    • 10
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 423-427
    Reactivity
    • 271
    • 162
    • 147
    • 35
    • 15
    • 14
    • 12
    • 11
    • 10
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 256
    • 27
    Rabbit
    Clonality
    • 245
    • 38
    Polyclonal
    Conjugate
    • 135
    • 21
    • 16
    • 14
    • 12
    • 10
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    This SMAD3 antibody is un-conjugated
    Application
    • 195
    • 127
    • 116
    • 81
    • 61
    • 56
    • 55
    • 53
    • 30
    • 14
    • 13
    • 10
    • 6
    • 5
    • 2
    • 2
    Immunofluorescence (IF), Immunohistochemistry (IHC)
    Specificity
    The antibody detects endogenous level of total Smad3 protein.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
    Immunogen
    Peptide sequence around AA 423-427 (C-S-S-V-S) derived from Human Smad3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Isotype
    IgG
  • Application Notes
    Immunohistochemistry: 1:50-1:100
    Immunofluorescence: 1:100-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    SMAD3
    Alternative Name
    Smad3 (SMAD3 Antibody Abstract)
    Synonyms
    madh3, madh3a, smad3, wu:fa99e03, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, XSmad3, XenMLP, Xmad3, madh3-A, Madh3, AU022421, Smad 3, mad3, SMAD family member 3, SMAD family member 3a, SMAD family member 3 L homeolog, SMAD3, smad3a, smad3.L, Smad3
    Background
    Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
    Molecular Weight
    52 kDa
    NCBI Accession
    NP_001138
    UniProt
    P84022
    Pathways
    Cell Division Cycle, Chromatin Binding, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Autophagy
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